Current status of basic and translational research on heat stress-induced damage to the testicular spermatogenic microenvironment
10.13263/j.cnki.nja.2025.10.011
- VernacularTitle:热应激导致睾丸生精微环境损伤的基础及转化研究现状
- Author:
Sirui ZHANG
1
;
Haiyang ZHAO
;
Hui WANG
Author Information
1. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166
- Publication Type:Journal Article
- Keywords:
heat stress;
spermatogenic microenvironment;
spermatogenesis;
male infertility
- From:
National Journal of Andrology
2025;31(10):932-941
- CountryChina
- Language:Chinese
-
Abstract:
Heat stress(HS)is a critical factor contributing to male infertility,primarily by disrupting the testicular spermatogenic microenvironment,leading to oligospermia,asthenospermia,teratospermia and other male healthcare con-cerns.Sertoli cells are the major components of spermatogenic microenvironment and the blood-testis barrier(BTB),provi-ding structural and nutritional support for spermatogenesis.HS impairs the structure and function of Sertoli cells and the BTB,disrupts the spermatogenesis,and damages other testicular cells and extracellular matrix components.Current re-search predominantly employs surgical or environmental simulation models.A large number of studies have found that natu-ral compounds and traditional Chinese medicines exhibit therapeutic potential through antioxidant,anti-apoptotic,and hor-mone synthesis-regulating mechanisms.Patent and market translation efforts focus on optimizing formulars and developing novel antioxidant molecules.This review systematically summarizes the mechanisms of HS-induced reproductive damage,advances in basic research,and translational progress,aiming to provide a theoretical foundation for clinical diagnosis,treatment,and product development,while enhancing awareness of male reproductive health protection.
