A case of whole-body rash caused by type Ⅰ cryoglobulin
10.3760/cma.j.cn114452-20241216-00684
- VernacularTitle:Ⅰ型冷球蛋白致周身皮疹1例
- Author:
Zhongwei JIA
1
;
Qiong LU
1
Author Information
1. 安徽医科大学第一附属医院检验科，合肥 230022
- Publication Type:Journal Article
- Keywords:
Urticaria;
Immunoglobulin M;
Electrophoresis;
Cryoglobulinemia
- From:
Chinese Journal of Laboratory Medicine
2025;48(6):750-753
- CountryChina
- Language:Chinese
-
Abstract:
A 65-year-old female patient was admitted to the First Affiliated Hospital of Anhui Medical University on July 31, 2024, due to "recurrent rash all over the body for more than 12 years and aggravation with fever for more than 20 days". The patient was previously diagnosed with acute urticaria due to full body rash with pruritus 12 years ago and treated with glucocorticoids. One year ago, she discontinued glucocorticoids at another hospital and was admitted to our hospital recently because of frequent rash and high fever. Elevated immunoglobulin M (IgM) was found from laboratory valuation and was identified as IgM kappa (IgM κ) monoclonal immunoglobulin by immunofixation electrophoresis. Cryoglobulin testing confirmed the presence of type I cryoglobulin (IgM κ type) in the blood. The patient was treated with oral colchicine tablets of 0.75 mg qd during hospitalization, resulting in partial remission. After discharge, the patient was treated with oral colchicine tablets 0.5 mg bid for maintenance treatment, and underwent regular outpatient follow-up every other month. By January 2025, the patient′s outpatient medical record showed that the rash was mostly controlled. If IgM κ type monoclonal immunoglobulin is present in the blood of patients with unexplained skin lesions, cryoglobulinemia needs to be considered clinically.
