Evolution and application of methodology in primary membranous nephropathy-associated antigens and antibodies
10.3760/cma.j.cn114452-20250927-00535
- VernacularTitle:原发性膜性肾病相关抗原抗体检测方法发展及应用
- Author:
Haoyuan CUI
1
;
Chao LI
1
;
Yubing WEN
1
;
Hang LI
1
;
Limeng CHEN
1
Author Information
1. 中国医学科学院北京协和医院肾内科，北京 100730
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, membranous;
Autoantibodies;
Target antigen;
Disease diagnosis
- From:
Chinese Journal of Laboratory Medicine
2025;48(6):763-769
- CountryChina
- Language:Chinese
-
Abstract:
Since the discovery of anti-phospholipase A2 receptor antibodies, the diagnosis of primary membranous nephropathy has evolved from reliance on renal tissue biopsy to the use of serum assays in certain patients, owing to continuously developing and improving methodologies. The advancement of detection methods and the discovery of new antigens are driving primary membranous nephropathy to personalized diagnosis and treatment. This article summarizes the evolution of antigens and antibodies detection techniques related to primary membranous nephropathy, aiming to explore the advantages, disadvantages, and possible future directions of methodology.
