Progress and problems of intratumoral microbiota in the occurrence and development of tumors
10.3760/cma.j.cn114452-20240806-00434
- VernacularTitle:肿瘤组织内菌群在肿瘤发生和发展中作用与思考
- Author:
Ke XU
1
;
Min LI
1
Author Information
1. 上海交通大学医学院附属仁济医院检验科，上海 200127
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Tumor microenvironment;
Microbiota
- From:
Chinese Journal of Laboratory Medicine
2025;48(6):774-779
- CountryChina
- Language:Chinese
-
Abstract:
Tumor stromal tissue and tumor cells constitute the majority of tumor tissue, and were long thought to be sterile. Advances in detection technology and an increasing understanding of the tumor microenvironment have revealed that microbiota with complex functions are potential components of the tumor microenvironment. Intratumoral microbiota can promote tumor development by regulating the immune microenvironment, activating oncogenic pathways, and secreting metabolites. Intratumoral microbiota can also predict tumor prognosis. Given the diversity of microorganisms, including bacteria, fungi, and viruses, and the body of research on the connection between microbiota and tumor, this review summarizes current methods for analyzing intratumoral microbiota, explores the association among intratumoral microbiota, tumorigenesis, tumor development, and tumor prognosis, and discusses unanswered questions in the study of intratumoral microbiota.
