New concepts, new indicators and new technologies of lipid management in laboratory medicine: application and prospect
10.3760/cma.j.cn114452-20250604-00324
- VernacularTitle:血脂管理新理念、新指标及新技术在检验医学中的应用与展望
- Author:
Jia WU
1
;
Junjun WANG
1
Author Information
1. 南京大学医学院附属金陵医院 解放军东部战区总医院检验科，南京210002
- Publication Type:Journal Article
- Keywords:
Atherosclerotic cardiovascular diseases;
Lipid management;
Omics Technologies;
Biomarkers;
Laboratory medicine
- From:
Chinese Journal of Laboratory Medicine
2025;48(7):791-794
- CountryChina
- Language:Chinese
-
Abstract:
Dyslipidemia is the core pathological basis of atherosclerotic cardiovascular diseases (ASCVD). Lipid management strategy undergoes the innovation from "single target" to "multi-dimensional precision" now. The application of apolipoprotein B in the risk management of ASCVD is explored in this paper, and it is highlighted that non-high-density lipoprotein cholesterol is a more reliable risk stratification indicator instead of high triglyceride level. Meanwhile, it is revealed that with the use of multi-omics technologies, the potential of epigenetic modifications and core molecules of lipid metabolism might serve as new indicators for ASCVD risk assessment. This paper also expands the cross-disciplinary multi-dimensional collaborative mechanisms of "heart-eye lipid metabolism association" and "gut-heart axis association", which is conducive to exploring new approaches for lipid management and intervention in ASCVD.
