Causal relationship between periodontal disease and prostate cancer:A two-sample bidirectional Mendelian randomization analysis in two races
10.13263/j.cnki.nja.2025.10.004
- VernacularTitle:牙周病与前列腺癌之间的因果关系:一项双样本双向孟德尔随机化分析
- Author:
Xiaoxu JIN
1
;
Jing LIU
;
Xiaodong ZHAO
;
Wenyi HUANG
;
Ning DONG
;
Shihao WANG
;
Mengfei MA
;
Yulin ZHOU
;
Yuhao CHEN
;
Jinlu SUN
;
Jie DONG
;
Jun HU
;
Song XU
Author Information
1. 南京大学医学院附属金陵医院泌尿外科,南京 210002
- Publication Type:Journal Article
- Keywords:
periodontal disease;
prostate cancer;
Mendelian randomization
- From:
National Journal of Andrology
2025;31(10):885-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to discuss the causal relationship between periodontal disease(PD)and prostate cancer(PCa).Methods A two-sample bidirectional Mendelian randomization(MR)analysis based on publicly statistical data from genome-wide association studies(GWAS)was conducted.MR Egger,weighted medium,simple mode and weighted mode were supplemented,while inverse variance weighted analysis(IVW)was the main method of analysis.Heterogeneity testing,pleiotropy testing and leave-one-out testing were used to assess the sensitivity and stabili-ty.Results The results of MR analysis showed that PD had no significant impact on the occurrence of PCa:East Asian(IVW,PD:OR=1.07,P=0.48);European(IVW,PD:OR=1.00,P=0.37,periodontitis:OR=1.03,P=0.14,chronic gingivitis:OR=0.99,P=0.37,chronic periodontitis:OR=1.03,P=0.22).The reverse MR analysis also did not show a causal relationship between PCa and PD:East Asian(IVW,PD:OR=0.97,P=0.22);European(IVW,PD:OR=0.84,P=0.44,periodontitis:OR=1.01,P=0.75,chronic gingivitis:OR=0.93,P=0.23,chronic periodontitis:OR=0.99,P=0.80).The results of other analysis were consistent with those of IVW analysis.Conclusions The results of our two-sample bidirectional MR analysis do not support a causal relationship between PD and PCa.
