Chemical constituents from Inula japonica and their anti-asthmatic activity
10.3969/j.issn.1001-1528.2025.10.017
- VernacularTitle:金沸草化学成分及其抗哮喘活性研究
- Author:
Yan ZHANG
1
;
Yan-rong GUO
;
Su-ping YU
;
Shu-ling WANG
;
Xiao-song CHEN
;
Yu-xia HAN
;
Ming-hao PENG
Author Information
1. 河南中医药大学儿科医学院,河南郑州 450000;河南中医药大学第一附属医院儿科医院,河南郑州 450000
- Publication Type:Journal Article
- Keywords:
Inula japonica Thunb.;
chemical constituents;
isolation and identification;
anti-asthmatic activity
- From:
Chinese Traditional Patent Medicine
2025;47(10):3283-3289
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Inula japonica Thunb.and their anti-asthmatic activity.METHODS Separation and purification were performed using silica gel and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The effect of compounds on the release rate of β-Hex was evaluated by substrate coloration method.RESULTS Twenty-three compounds were isolated and identified as dehydrodontic acid(1),vitexin(2),alternariol(3),globuxanthone(4),1,3,6,7-tetrahydroxyxanthone(5),hydroxyhydrolapachol(6),isoscopoletin(7),elephanmollen(8),benzoylcholine(9),hoconobiflavone(10),clovandiol(11),hydroxydihydrobovolide(12),5,7-dihydroxycoumarin(13),scopoletin(14),orlichenol glucoside(15),urolignoside(16),9-angeloyloxythymol(17),6,3′,4′-trihydroxyaurone(18),flufuran(19),sweroside(20),guajadial(21),5,7,4′-trimethoxy-4-phenylcoumarin(22),dibutylphthalate(23).After intervention with compounds 9 and 16,the release rates of β-Hex were(56.64±2.37)％and(58.07±2.29)％,respectively.CONCLUSION Compounds 1-23 are isolated from Ⅰ.japonica for the first time.Compounds 9 and 16 have anti-asthmatic activity.
