Advances in laboratory diagnosis techniques of occult hepatitis B virus infection
10.3760/cma.j.cn114452-20250211-00076
- VernacularTitle:隐匿性乙型肝炎病毒感染实验室诊断技术进展
- Author:
Tianwei ZHANG
1
;
Ning LI
1
;
Yanqiu XU
1
;
Yong WANG
1
;
Fang LUAN
1
Author Information
1. 山东第一医科大学附属省立医院临床医学检验部，济南 250021
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Hepatitis B virus;
Hepatitis B surface antigens;
Clinical laboratory techniques
- From:
Chinese Journal of Laboratory Medicine
2025;48(6):780-784
- CountryChina
- Language:Chinese
-
Abstract:
Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of replicable viral DNA in the liver of individuals with negative hepatitis B surface antigen (HBsAg), while HBV DNA can be detectable or undetectable in the serum, which is a special form of HBV DNA infection. In OBI carriers, the negative HBsAg in blood and the extremely low or fluctuating content of HBV DNA make it difficult in clinical detection. There is a risk for developing into occult cirrhosis and liver cancer, and it increases the potential danger of hepatitis B virus transmission during blood transfusion, hemodialysis and organ transplantation. Therefore, deep study of the pathogenic mechanism of OBI and searching for specific and sensitive detection markers are crucial for more timely and standardized diagnosis, treatment and prevention. This paper reviews the current situation of occult hepatitis B virus infection and the development of laboratory detection techniques in recent years, and discusses more efficient laboratory diagnostic techniques and markers based on its potential pathogenic mechanism.
