Analysis of frailty status and risk factors in elderly patients with AIDS and opportunistic infection
10.11816/cn.ni.2025-250948
- VernacularTitle:老年艾滋病合并机会性感染患者衰弱现状及危险因素
- Author:
Chan YAN
1
;
Cong LIU
1
;
Jinhua JIAO
1
;
Lujun WEN
1
;
Ting WANG
1
;
Yan WANG
1
Author Information
1. 广州医科大学附属市八医院感染科,广东 广州 510440
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Frailty;
Elderly;
Risk factor
- From:
Chinese Journal of Nosocomiology
2025;35(20):3115-3118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the frailty status of elderly patients with acquired immune deficiency syn-drome(AIDS)and opportunistic infection,and to analyze the associated risk factors.METHODS A convenience sampling method was used to survey 210 elderly patients with AIDS and opportunistic infection in Guangzhou from May 2024 to Apr.2025.General information questionnaires,FRAIL scale,Nutritional Risk Screening 2002,Athens Insomnia Scale and objective biological indicators were utilized to investigate the incidence of frailty.Logis-tic regression analysis was employed to identify the risk factors for frailty in elderly patients with AIDS and oppor-tunistic infection.RESULTS Among the 210 elderly patients with AIDS and opportunistic infection,40(19.05％)were frail,including 20(15.62％)patients aged＜60 years and 20(24.39％)≥60 years.Advanced age(OR=1.111,95％CI:1.033-1.194,P=0.004),body mass index(BMI)≥ 24.0 kg/m2(OR=4.329,95％CI:1.008-18.1585,P=0.049),hemoglobin level(OR=1.037,95％CI:1.009-1.065,P=0.009)and CD4+T lymphocyte count＜200(OR=10.792,95％CI:1.358-85.765,P=0.024)were identified as risk factors for frailty.Regular exercise(OR=0.108,95％CI:0.032-0.362,P＜0.001)was found to be a protective factor.CONCLUSIONS Elderly patients with AIDS and opportunistic infection experience early onset and high inci-dence of frailty,influenced by multiple factors.Early intervention,enhanced nutrition and engaging in regular ex-ercise can reduce the occurrence of frailty.
