Clinical features and risk factors for poor prognosis in patients with invasive pulmonary aspergillosis
10.11816/cn.ni.2025-250458
- VernacularTitle:侵袭性肺曲霉病患者临床特征及其预后不良危险因素
- Author:
Hongfang ZHANG
1
;
Hongyin WANG
;
Mingxia CHEN
;
Hongyi LIN
Author Information
1. 东南大学附属中大医院感染管理科,江苏南京 210009
- Publication Type:Journal Article
- Keywords:
Invasive pulmonary aspergillosis;
Clinical feature;
Poor prognosis;
Risk factor;
Lymphocyte;
Inten-sive care unit
- From:
Chinese Journal of Nosocomiology
2025;35(20):3095-3099
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the pathogenic characteristics and clinical features of patients with invasive pul-monary aspergillosis(IPA)and summarize the risk factors for poor prognosis.METHODS The clinical data of 89 patients diagnosed with IPA based on microbial identification of Aspergillus from sputum or bronchoalveolar lav-age fluid cultures and diagnostic criteria,who were admitted to Zhongda Hospital Southeast University from Aug.2022 to Jul.2024 and were queried by electronic case system,were analyzed retrospectively.The distribu-tion of Aspergillus pathogens and clinical features of patients with IPA were analyzed,and the risk factors for poor prognosis were summarized.RESULTS A total of 107 Aspergillus strains were isolated from 89 cases,including 55 strains of Aspergillus fumigatus(51.40％),30 strains of Aspergillus flavus(28.04％)and 10 strains of As-pergillus niger(9.34％).There were 63 m ale patients(70.79％),and 34 cases had poor prognosis.Baseline pe-ripheral blood lymphocyte count(＜0.645×109)(OR=6.653,95％CI:2.013-21.990,P=0.002)and ICU admission(OR=8.303,95％CI:1.283-53.741,P=0.026)were identified as risk factors for poor prognosis in patients with IPA.Receiver operating characteristic curve analysis showed that the cut-off point for baseline pe-ripheral blood lymphocyte count in predicting prognosis in patients with IPA was 0.645 ×109/L,with a sensitivity of 85.22％and a specificity of 69.67％.CONCLUSIONS Baseline peripheral blood lymphocyte count and ICU ad-mission are risk factors for poor prognosis in patients with IPA.The alert value for baseline peripheral blood lym-phocyte count is 0.645 × 109/L,which has good predictive value for the occurrence of poor prognosis.
