Risk factors for PICC central line-associated bloodstream infection in cancer patients
10.11816/cn.ni.2025-250858
- VernacularTitle:肿瘤患者PICC导管相关血流感染的危险因素
- Author:
Yuanyuan NIU
1
;
Weiwei YANG
1
;
Dina ZHANG
1
;
Bing LUO
1
Author Information
1. 中国人民解放军空军军医大学第一附属医院消化内科,陕西西安 710032
- Publication Type:Journal Article
- Keywords:
Central line-associated bloodstream infection;
Cancer patient;
Influencing factor;
Management strategy
- From:
Chinese Journal of Nosocomiology
2025;35(20):3147-3150
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the risk factors for peripherally inserted central catheter(PICC)central line-as-sociated bloodstream infection in cancer patients and explore corresponding management strategies.METHODS The data of 52 chemotherapy patients with PICC central line-associated bloodstream infection(PICC-CLABSI)ad-mitted to the Department of Gastroenterology of the First Affiliated Hospital of Air Force Medical University be-tween May 2021 and May 2023 were collected retrospectively,and the patients were classified as the infection group.Additionally,183 chemotherapy patients without PICC-CLABSI during the same period were included as the non-infection group.Clinical data from both groups were collected.Logistic regression analysis was used to identify risk factors for PICC-CLABSI in cancer patients,and receiver operating characteristic(ROC)curves were employed to assess the accuracy of predictive variables.RESULTS A total of 57 pathogens were isolated from 52 patients with PICC-CLABSI,including 15 strains of Escherichia coli,12 strains of Klebsiella pneumoniae,9 strains of Pseudomonas aeruginosa and 9 strains of Staphylococcus aureus.Diabetes(OR=2.694),catheter in-dwelling time≥30 d(OR=7.146),number of chemotherapy(OR=6.617),maintenance frequency of once per week(OR=2.803)and maintenance method(OR=6.289)were identified as risk factors for PICC-CLABSI(P＜0.05).The area under the curve for the combined prediction of PICC-CLABSI was 0.904,with a sensitivity of 0.750 and a specificity of 0.907.CONCLUSIONS Diabetes,catheter indwelling time and number of chemotherapy are risk factors for PICC-CLABSI,while a maintenance frequency of once per week and the maintenance method are protective factors.Close attention should be paid to the assessment of risk factors after catheter placement,and targeted anti-infection strategies should be implemented.
