Progress of research on mechanisms and clinical applications of novel antibacterial materials in treating infectious bone defect
10.11816/cn.ni.2025-250420
- VernacularTitle:新型抗菌材料治疗感染性骨缺损的机制与临床应用研究进展
- Author:
Xing YANG
1
;
Mingwang ZHOU
;
Xiaoping WANG
;
Haiyuan GAO
;
Xinhao LI
Author Information
1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
Infectious bone defect;
Antibacterial material;
Bacterial infection;
Bone repair
- From:
Chinese Journal of Nosocomiology
2025;35(19):3031-3035
- CountryChina
- Language:Chinese
-
Abstract:
Infectious bone defect,one of the complex and refractory types of bone defects,is characterized by infec-tion,inflammation and subsequent bone tissue destruction.These conditions often lead to severe consequences such as limb necrosis,dysfunction or even amputation.The previous treatment method for infectious bone defect primarily involves thorough debridement and bone grafting after infection control with antibacterial drugs.Howev-er,this method carries drawbacks,including the possibility of drug resistance and systemic toxicity due to high-dose use of antimicrobial drugs.With advancements in modern medicine and in-depth research on biomaterials,va-rious novel antibacterial materials have been increasingly applied in the treatment of infectious bone defect,demon-strating promising outcomes.This paper reviews the applications and therapeutic efficacy of novel antibacterial ma-terials in treating infectious bone defect at home and abroad,aiming to provide references for clinical management.
