Analysis of risk factors of pulmonary thromboembolism in patients with pulmonary tuberculosis
10.3760/cma.j.cn311365-20240618-00176
- VernacularTitle:肺结核患者并发肺血栓栓塞症的危险因素分析
- Author:
Xiaoqian HU
1
;
Xu ZHANG
;
Yuanbo LAN
;
Liang ZHOU
;
Jianyong ZHANG
Author Information
1. 遵义医科大学附属医院呼吸与危重症医学科，遵义 563000
- Publication Type:Journal Article
- Keywords:
Tuberculosis, pulmonary;
Risk factors;
Pulmonary thromboembolism
- From:
Chinese Journal of Infectious Diseases
2024;42(11):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors of pulmonary thromboembolism (PTE) in patients with pulmonary tuberculosis (PTB), to improve the awareness of clinicians.Methods:A total of 120 PTB patients complicated with PTE (PTE group) and 120 PTB patients without PTB (control group) admitted to the Affiliated Hospital of Zunyi Medical University from January 2018 to December 2022 were included. Clinical data from both groups were collected and compared. Statistical analyses were performed using the chi-square tests and Mann-Whitney U test, and binary logistic regression analysis was performed to identify the risk factors for PTE in PTB patients. Results:The age of the PTE group was 69.00(63.00, 76.75) years. The rates of comorbid chronic pulmonary diseases, respiratory failure, and diabetes in PTE group were 40.00%(48/120), 24.17%(29/120), and 12.50%(15/120), respectively.The incidence rates of dyspnea, chest distress, chest pain, and palpitations in PTE group were 80.83%(97/120), 21.67%(26/120), 23.33%(28/120), and 10.00%(12/120), respectively. The D-dimer level in PTE group was 3.34 (2.05, 6.60) mg/L. These results were all higher than those in the control group (10.00%(12/120), 7.50%(9/120), 3.33%(4/120), 36.67%(44/120), 6.67%(8/120), 13.33%(16/120), 3.33%(4/120), and 0.97(0.41, 2.11) mg/L, respectively). The differences were all statistically significant ( χ2=28.80, 12.51, 6.92, 48.30, 11.10, 4.01 and 4.29, respectively, Z=-8.76; all P<0.05). Binary logistic regression analysis revealed that older age (odds ratio( OR)=1.057), comorbid chronic pulmonary diseases ( OR=2.998), diabetes ( OR=8.703), presence of dyspnea ( OR=5.132), and elevated D-dimer levels ( OR=1.672) were independent risk factors for PTE in PTB patients (all P<0.05). Conclusions:Older age, comorbid chronic pulmonary diseases, diabetes, dyspnea and elevated D-dimer levels are risk factors for PTE in PTB patients. Clinicians should remain vigilant to these factors to reduce the risk of missing PTE in this population.
