Progress of research on drug resistance mechanisms of coagulase-negative Staphylococci and intervention measures
10.11816/cn.ni.2025-250333
- VernacularTitle:凝固酶阴性葡萄球菌耐药机制及其干预研究进展
- Author:
Ruixue LI
1
;
Liang LIANG
;
Pengfei JIN
;
Wenfeng XU
Author Information
1. 北京医院药学部/国家老年医学中心中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室北京医院,北京 100730;北京大学药学院药事管理与临床药学系,北京 100191;西藏自治区人民医院药学部,西藏拉萨 850000
- Publication Type:Journal Article
- Keywords:
Coagulase-negative Staphylococcus;
Drug resistance mechanism;
Biofilm;
Control strategy
- From:
Chinese Journal of Nosocomiology
2025;35(18):2856-2860
- CountryChina
- Language:Chinese
-
Abstract:
Coagulase-negative Staphylococci(CoNS)are a group of gram-positive cocci incapable of producing co-agulase,which distinguishes them from Staphylococcus aureus.CoNS are widely distributed in natural environ-ment and are commonly found on skin,mucous membranes and other host-associated tissues.In recent years,CoNS have become one of the significant pathogenic factors for hospital-associated infections and have been partic-ularly prevalent among the patients with impaired immune function.Although the pathogenicity of CoNS is gener-ally considered lower than that of coagulase-positive Staphylococci,the widespread use of implanted medical de-vices and extensive use of antibiotics has led to increasingly serious problems of drug resistance,which has atta-ched great importance to the hospital.The databases such as PubMed,Embase and CNKI were retrieved to reveal the drug resistance mechanisms of CoNS,aiming to push forward the research and development of new drugs against drug-resistant bacteria and emerging diagnosis and treatment measures and provide scientific bases for sol-ving the problems of antibiotics resistance around the globe.
