Effect of azvudine on prevention of SARS-CoV-2 infection among population of close contact with families with symptomatic SARS-CoV-2 infection
10.11816/cn.ni.2025-246614
- VernacularTitle:阿兹夫定对有症状新型冠状病毒感染家庭密切接触者的预防作用
- Author:
Chao JIANG
1
;
Xuping DENG
;
Hai FAN
;
Peng JIANG
Author Information
1. 马鞍山市人民医院药事科,安徽马鞍山 243000
- Publication Type:Journal Article
- Keywords:
Azvudine;
SARS-CoV-2 infection;
Close contact with family;
Prevention;
Safety
- From:
Chinese Journal of Nosocomiology
2025;35(18):2736-2740
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE T o explore the effectiveness and safety of azvudine in prevention of SARS-CoV-2 infection among the population of close contact with families with symptomatic SARS-CoV-2 infection.METHODS A total of 64 people who were closely contact with the families with symptomatic SARS-CoV-2 infection and were trea-ted in Ma'anshan People's Hospital from Jan.2023 to Oct.2023 were enrolled in the study and randomly divid-ed into the group A with 22 cases,the group B with 17 cases and the group C with 25 cases.The group A was giv-en 5mg of azvudine,the group B was given 3mg of azvudine plus 2mg of placebo,and the group C was given 5 mg of azvudine;all the three groups were treated for 7 days in total.The incidence of SARS-CoV-2 infection and the levels of interleukin-6(IL-6),C-reactive protein(CRP),immunoglobulin G(IgG)and immunoglobulin M(IgM)were observed among the three groups of research subjects after the drug therapies;the adverse reactions were re-corded during the research period.RESULTS The incidence rate of SARS-CoV-2 infection was 4.55％in the group A,11.76％in the group B,12.00％in the group C,and there was no significant difference(x2=0.921,P=0.631).There were no significant differences in the levels of IL-6,CRP,IgG and IgM among the three groups be-fore and after the drug therapies.The incidence of adverse reactions such as fatigue,cough,hypertriglyceridemia and gastrointestinal tract reactions was 9.09％in the group A after the drug therapies,11.76％in the group B,12.00％in the group C,and there was no significant difference.CONCLUSION There is no significant difference in the effectiveness of azvudine in prevention of SARS-CoV-2 infection among the population of close contact with families with symptomatic SARS-CoV-2 infection,with the safety and tolerance favorable.
