Research progress of ADAMTS13 in immune thrombotic thrombocytopenic purpura
10.3760/cma.j.cn114452-20250224-00102
- VernacularTitle:ADAMTS13在免疫性血栓性血小板减少性紫癜中的研究进展
- Author:
Liubing LI
1
;
Min LIU
1
Author Information
1. 中山大学附属第一医院医学检验科，广州 510080
- Publication Type:Journal Article
- Keywords:
ADAMTS13;
Purpura, thrombocytopenic;
Pathogenesis
- From:
Chinese Journal of Laboratory Medicine
2025;48(4):538-542
- CountryChina
- Language:Chinese
-
Abstract:
Immune thrombotic thrombocytopenic purpura (iTTP) is a fatal thrombotic microvascular disease closely associated with a severe deficiency of a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13). This review summarized the role of ADAMTS13 in the pathogenesis and clinical diagnosis and treatment of iTTP, as well as the detection of plasma ADAMTS13.
