Value of microbiological rapid on-site evaluation in treatment of patients with severe community-acquired pneumonia
10.11816/cn.ni.2025-250211
- VernacularTitle:微生物学快速现场评估在重症社区获得性肺炎治疗中的应用价值
- Author:
Junchen XIONG
1
;
Lihua QIU
;
Ning LIU
;
Lili SHI
;
Liming SUN
;
Xiaosheng MENG
;
Huade ZHENG
;
Jiguang MENG
Author Information
1. 安徽医科大学第五临床医学院海军临床学院,安徽 合肥 230032;解放军总医院第六医学中心呼吸与危重症医学科,北京 100048
- Publication Type:Journal Article
- Keywords:
Severe community-acquired pneumonia;
Bronchoalveolar lavage fluid;
Microbiological rapid on-site evaluation;
Antimicrobial treatment;
Curative effect
- From:
Chinese Journal of Nosocomiology
2025;35(17):2618-2623
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the value of microbiological rapid on-site evaluation(M-ROSE)technique in treatment of the patients with severe community-acquired pneumonia(SCAP).METHODS A total of 124 patients with SCAP who were treated in the department of respiratory and critical care medicine of The Fourth Medical Center of Chinese PLA General Hospital from Sep.2023 to Dec.2024 were enrolled in the study and were random-ly divided into the M-ROSE group and the control group in a 1∶1 ratio based on the status of M-ROSE for bron-choalveolar lavage fluid(BALF).The M-ROSE test and conventional etiological test[metagenomic next genera-tion sequencing(mNGS),smear,culture]were performed for the M-ROSE group,and the conventional etiologi-cal test was only carried out for the control group.The baseline data,symptoms and signs,C-reactive protein lev-el,treatment status and outcomes were observed and compared between the two groups of patients.RESULTS A-mong the 62 patients for whom the BALF specimens were detected with M-ROSE,45(72.58％)patients showed the consistent test result for fungi with mNGS,47(75.81％)patients showed the same test result for cocci with mNGS,and 30(48.39％)patients showed the same test result for bacilli with mNGS.The duration of the M-ROSE test was 1.50(1.50,2.00)h,shorter than that of the smear,culture and mNGS(P＜0.05).The body temperature returning to the normal and the property,volume of sputum were improved more early in days in the M-ROSE group than in the control group after the anti-infection treatment(P＜0.05);the level of inflammatory factor CRP declined more quickly in the M-ROSE group than in the control group(P＜0.05);the effective rates of treatment of the M-ROSE group were higher than those of the control group after the hospitalization for 3,5 and 7 days(P＜0.05).CONCLUSION The M-ROSE test for BALF may facilitate the rapid etiological diagnosis for the patients with SCAP in early stage,provide guidance for the anti-infection treatment strategies,and accelerate the improvement of symptoms and inflammatory factors;it has certain clinical application value.
