Epidemiological characteristics,virulence and drug resistance genes in Klebsiella oxytoca complex isolated from children in Suzhou
10.11816/cn.ni.2025-250921
- VernacularTitle:苏州地区儿童产酸克雷伯菌复合群的流行特征及毒力和耐药基因分析
- Author:
Xiuxiu ZHENG
1
;
Mi ZHOU
;
Yu CAO
;
Zhenjiang BAI
;
Lili HUANG
Author Information
1. 苏州大学附属儿童医院检验科,江苏苏州 215200
- Publication Type:Journal Article
- Keywords:
Klebsiella oxytoca complex;
Drug resistance analysis;
Child;
Virulence gene;
Drug resistance gene
- From:
Chinese Journal of Nosocomiology
2025;35(17):2581-2585
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the epidemiological characteristics,virulence and drug resistance genes in Kleb-siella oxytoca complex(KOX)strains isolated from the children in Suzhou so as to provide theoretical bases for clinical prevention and control.METHODS The clinical distribution and drug resistance of 101 strains of KOX that were isolated from Children's Hospital of Soochow University from Jan.2021 to Mar.2024 were retrospectively analyzed.Fifty strains were randomly selected to detect the expressions of 18 types of virulence genes and 12 types of drug resistance genes.RESULTS Of the 97 strains of KOX isolated from hospitalized children,32.67％from i-solated from sputum,27.72％from stools and 24.74％from urine;45.54％were isolated from hematology de-partment,18.81％from neonatology department and 10.89％from ICU.The strains expressed a variety of viru-lence genes,among which the ironophore-related genes entB(82.00％),irp-1(64.00％),irp-2(64.00％),ybtS(64.00％)and fyuA(64.00％)were dominant.Carbapenem-sensitive KOX(CS-KOX)strains were susceptible to most of the antibiotics,while the drug resistance rates of the CR-KOX strains to most of the antibiotics were relatively high.The detection rates of extended-spectrum β-lactamase gene CTX(56.52％)and carbapenemase gene NDM(78.26％)were relatively high among the CR-KOX strains;38.89％(7/18)of the strains expressed NDM gene and meanwhile expressed other carbapenemase genes.CONCLUSIONS The KOX strains isolated from the hospitalized children in Suzhou carry a variety of virulence and drug resistance genes,and there is risk of trans-mission of CR-KOX in the hospital.Therefore,it is necessary to attach great importance to the surveillance of drug-resistant strains for the long-term hospitalized children and raise the awareness of infection control so as to prevent the transmission of such bacteria.
