Impact of strengthened link quality of intervention measures on incidence of carbapenem-resistant Klebsiella pneumoniae infection in ICU patients
10.11816/cn.ni.2025-258019
- VernacularTitle:强化环节质量干预措施对ICU耐碳青霉烯类肺炎克雷伯菌医院感染率的影响
- Author:
Wenzhi HUANG
1
;
Fu QIAO
;
Jingwen LI
;
Linzhi CHENG
;
Yuhua DENG
;
Zhiyong ZONG
;
Wei ZHANG
Author Information
1. 四川大学华西医院感染性疾病中心,四川成都 610000;四川大学华西医院医院感染管理部,四川成都 610000
- Publication Type:Journal Article
- Keywords:
Carbapenem-resistant Klebsiella pneumoniae;
Link quality;
Interrupted time series model;
Hospital-associated infection;
Intervention measure
- From:
Chinese Journal of Nosocomiology
2025;35(17):2561-2565
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the effects of measures dominated by intensifying link quality on prevention and control of carbapenem-resistant Klebsiella pneumoniae(CRKP)among general ICU patients.METHODS The conventional intervention measures were taken from Jan.2016 to Oct.2020,which was assigned as the pre-inter-vention period;the intervention measures dominated by enhancement of link quality were taken for the general ICU patients(the study group)from Nov.2020 to Oct.2021,which was set as the intervention period,the inter-vention measures were taken for the neurosurgery ICU patients and the surgery ICU patients(the control group).A two-group interrupted time series of a quasi-experimental study was analyzed,and whether or not the intervention measures could reduce the incidence of CRKP hospital-associated infection among the general ICU patients was evaluated.RESULTS A total of 23 713 case-times of patients from three ICU wards were enrolled in the study.The incidence of CRKP hospital-associated infection among the general ICU patients was 4.49 cases per thousand patient-days during intervention period,3.71 cases per thousand patient-days during pre-intervention pe-riod,and there was no significant difference(u=-1.412,P=0.079);it was lower than 7.06 cases per thousand patient-days during nearly one year before the intervention period(from Nov.2019 to Oct.2020),and there was significant difference(u=3.128,P=0.002).The result of analysis of the interrupted time series showed that there was significant difference in the slope change between the study group and the control group after the inter-vention(P=0.035),indicating that the intervention measures could reduce the incidence of CRKP hospital-associ-ated infection in the study group,and there was significant difference in the changing trend between the study group and the control group.CONCLUSIONS The prevention and control measures for CRKP dominated by the link quality management can effectively reduce the incidence of CRKP hospital-associated infection among the gen-eral ICU patients.The prevention and control strategies may provide reference for prevention and control of CRKP in ICUs of other medical institutions.
