Resting-state functional connectivity changes of mirror neuron system brain regions in male nicotine addicts
10.13929/j.issn.1003-3289.2025.09.009
- VernacularTitle:尼古丁成瘾男性镜像神经元系统脑区静息态功能连接变化
- Author:
Ruiyang LI
1
;
Jianjun ZHANG
1
;
Qiaoli ZHANG
1
;
Mei XIE
1
;
Zhiqiang LI
1
;
Dongyan CHEN
1
;
Siyin LI
1
;
Tao WANG
1
Author Information
1. 浙江医院放射科,浙江 杭州 310013
- Publication Type:Journal Article
- Keywords:
male;
tobacco use disorder;
mirror neurons;
functional network;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(9):1498-1501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe resting-state functional connectivity(rs-FC)changes of mirror neuron system(MNS)brain regions in male nicotine addicts,and to explore their correlations with the degree of addiction.Methods Twenty-five male nicotine addicts(addiction group)and 27 healthy males(control group)were prospectively recruited,and resting-statefunctional MR scanning was performed.The general information and rs-FC values were compared between groups,and correlations of rs-FC values with Fagerstr?m test for nicotine dependence(FTND)and heaviness of smoking index(HSI)scale scores in addiction group were analyzed.Results No significant difference of age nor education level was found between groups(both P＞0.05).Compared to control group,rs-FC values between left inferior frontal gyrus(IFG.L)and right middle temporal gyrus(MTG.R)as well as right middle occipital gyrus(MOG.R)increased(GRF corrected,voxel-level P＜0.005,cluster-level P＜0.05),while between right fusiform gyrus(FFG.R)and right dorsal cingulate gyrus(DCG.R),right supplementary motor area(SMA.R),left medial superior frontal gyrus(SFGmed.L)and left supplementary motor area(SMA.L)decreased(GRF corrected,voxel-level P＜0.005,cluster-level P＜0.05).In addiction group,rs-FC value between IFG.L and MTG.R was negatively correlated with HSI scale score(r=-0.457,P=0.022),while that between IFG.L and MOG.R was negatively correlated with HSI scale and FTND scores(r=-0.440,-0.458,P=0.028,0.021).Conclusion There were specific changes of rs-FC patterns of MNS brain regions in male nicotine addicts,which were correlated with the degree of addiction.
