Correlation between changes of brain region volume and cognitive function in patients with temporal lobe epilepsy
10.13929/j.issn.1003-3289.2025.09.006
- VernacularTitle:颞叶癫痫患者脑区体积变化与认知功能的相关性
- Author:
Jiachen LI
1
;
Jingjing HAN
;
Guangyao LIU
;
Wanjun HU
;
Wenjing HUANG
;
Min LI
;
Jing ZHANG
Author Information
1. 兰州大学第二医院核磁共振科,甘肃兰州 730000;兰州大学第二临床医学院,甘肃兰州 730000;甘肃省功能及分子影像临床医学研究中心,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
epilepsy,temporal lobe;
hippocampal;
thalamus;
cognition disorders;
magnetic resonance imaging;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(9):1483-1487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the volume changes of brain regions and their correlation with cognitive function in temporal lobe epilepsy(TLE)patients.Methods Fifty TLE patients(TLE group)and 34 healthy controls(control group)were prospectively enrolled.Brain 3D-T1WI was collected,brain regions were delineated with automated segmentation technique,and hippocampus was segmented additionally with hippocampal brain template(HBT).The volume of brain regions were compared between groups,and the correlation of brain region volume with Montreal cognitive assessment(MoCA)score were analyzed.Results Compared with control group,in TLE group,bilateral cerebrum white matter,right globus pallidus,left posterior cingulate gyrus,left precentral gyrus,right fusiform gyrus,left cerebellum white matter,corpus callosum,left hippocampus(HBT segmentation and conventional segmentation)and right thalamus volumes decreased significantly(all P＜0.05),while right choroid plexus volume increased significantly(P＜0.05).The volume of left hippocampus(HBT segmentation)and right fusiform gyrus were both positively correlated with MoCA score in TLE group(r=0.335,0.376,P=0.009,0.007).Conclusion Widespread atrophy of brain regions could be seen in TLE patients,which were correlated with cognitive function.
