Clinical efficacy and mechanism of Shenqi Shiyiwei granules on improving colorectal cancer anemia based on network pharmacology
10.3969/j.issn.1673-9701.2025.26.012
- VernacularTitle:基于网络药理学的参芪十一味颗粒改善大肠癌肿瘤性贫血的临床效果与作用机制
- Author:
Mingyi HONG
1
;
Ken WANG
1
;
Qingfang JIAO
1
;
Wenling LONG
1
;
Zhen ZHANG
1
;
Hong WANG
1
;
Wanquan YANG
1
Author Information
1. 四川省中西医结合医院武侯肿瘤科一病区,四川成都 610041
- Publication Type:Journal Article
- Keywords:
Network pharmacology;
Shenqi Shiyiwei granules;
Colorectal cancer anemia
- From:
China Modern Doctor
2025;63(26):46-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect and mechanism of Shenqi Shiyiwei granules(SQSYW)on improving colorectal cancer anemia.Methods Through database and network pharmacology analysis,the potential targets and core genes of SQSYW in the treatment of colorectal cancer anemia were obtained.The potential gene targets were analyzed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes.A total of 80 patients with colorectal cancer anemia admitted in Sichuan Provincial Hospital of Integrated Traditional Chinese and Western Medicine were selected as subjects,according to the treatment plan,they were divided into experimental group(n=40)and control group(n=40).Control group received standard Western medical treatment including subcutaneous erythropoietin injections,while experimental group received additional administration of SQSYW on the base of control group's treatment regimen.Effective treatment rates,TCM symptom score,hemoglobin levels,and red blood cell counts were compared between two groups.Results Five key active ingredients,10 core targets and 30 main pathways were identified through pharmacological screening.Red blood cell count,hemoglobin,TCM syndrome and overall western medicine efficacy were better in experimental group than in control group(P＜0.05).Conclusion SQSYW can treat colorectal cancer anemia through multiple components,multiple targets and multiple pathways.The treatment effect of colorectal cancer anemia combined with SQSYW is better than that of simple western medicine.
