Causal association between serum 25-hydroxyvitamin D and tic disorder based on Mendelian randomization analysis
10.3969/j.issn.1673-9701.2025.26.010
- VernacularTitle:基于孟德尔随机化分析的血清25羟维生素D与抽动障碍的因果关联研究
- Author:
Yilong REN
1
;
Chunming JIANG
Author Information
1. 浙江中医药大学第四临床医学院,浙江 杭州 310053
- Publication Type:Journal Article
- Keywords:
25-hydroxyvitamin D;
Tic disorder;
Mendelian randomization;
Causal relationship
- From:
China Modern Doctor
2025;63(26):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal association between serum 25-hydroxyvitamin D[25(OH)D]and tic disorder(TD)based on two sample Mendelian randomization(TSMR)analysis.Methods Single nucleotide polymorphisms(SNP)associated with exposure and outcome were selected from the Genome-Wide Association Studies datasets of the publicly gene databases.Serum 25(OH)D was taken as the exposure factor and TD as the outcome factor.The inverse variance weighted(IVW)method was used as the main analysis method for data analysis and visualization.Results Forward Mendelian randomization(MR)analysis included 75 25(OH)D SNPs.IVW results showed no statistically significant difference in the effect of serum 25(OH)D levels on TD.In the reverse MR analysis involving 5 TD SNPs,the IVW results indicated no statistically significant impact of TD on serum 25(OH)D levels.All auxiliary method results demonstrated no causal association between TD and serum 25(OH)D levels(P＞0.05).Conclusion Through the analysis of TSMR,the results showed that there was no direct causal relationship between serum 25(OH)D level and TD,and 25(OH)D may affect TD through indirect action.
