Study on the diagnostic value of CCDC83,CEA and CA199 detection in colorectal cancer
10.3969/j.issn.1673-9701.2025.26.004
- VernacularTitle:CCDC83、CEA、CA199检测对结直肠癌的诊断价值研究
- Author:
Kai CHEN
1
;
Hong JIN
;
Shoukun LIANG
;
Li TANG
;
Qin WANG
;
Chunxiao HE
;
Runyuan ZHANG
;
Yu GAN
;
Li ZHANG
Author Information
1. 牡丹江医科大学附属红旗医院检验科,黑龙江牡丹江 157011
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Containing-coiled domain protein 83;
Diagnostic value
- From:
China Modern Doctor
2025;63(26):13-15,20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of coiled-coil domain containing 83(CCDC83),carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)199 detection in patients with colorectal cancer(CRC).Methods A total of 168 patients with colorectal diseases and 80 healthy physical examination subjects admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from September 2022 to January 2025 were selected as the study objects.Participants were classified into three groups based on pathological diagnosis and colonoscopy findings:colorectal cancer group(n=80),colorectal benign disease group(n=88),and healthy control group(n=80).Serum samples from all three groups were collected for detection of CCDC83,CEA,and CA199 expression levels.The diagnostic value was analyzed using receiver operating characteristic(ROC)curves.Results Colorectal cancer group exhibited significantly higher expression levels of CCDC83,CEA,and CA199 compared to colorectal benign disease group and healthy control group,with statistically significant differences(P＜0.05).ROC curve analysis demonstrated diagnostic value for CCDC83,CEA,and CA199,with CCDC83 showed superior specificity compared to CEA and CA199.Conclusion CCDC83,CEA and CA199 showed good diagnostic efficacy for colorectal cancer.
