Chemical constituents from the bark of Toona sinensis and their anti-inflammatory activity
10.3969/j.issn.1001-1528.2025.09.019
- VernacularTitle:香椿树皮化学成分及其抗炎活性研究
- Author:
Wei WU
1
;
Shou-mao SHEN
;
Yan-ni WANG
;
Xia ZHANG
;
Jin-yu LI
;
Wei-dong PAN
Author Information
1. 贵州大学药学院,贵州贵阳 550025
- Publication Type:Journal Article
- Keywords:
Toona sinensis(A.Juss.)Roem.;
bark;
polyacetylene;
chemical constituents;
isolation and identification;
anti-inflammatory activity
- From:
Chinese Traditional Patent Medicine
2025;47(9):2950-2956
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the bark of Toona sinensis(A.Juss.)Roem and their anti-inflammatory activity.METHODS Silica gel,RP-18 reverse phase silica gel and HPLC were used for isolation and purification,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activity were evaluated by RAW264.7 model.RESULTS Sixteen compounds were isolated and identified as(9Z)-18-hydroxyo-ctadec-9-en-4,6-diyn-3-one(1),toonapolyyne C(2),(9S,10E,16R)-octadec-10-ene-12,14-diyne-1,9,16-triol(3),(9S,10E,16R)-9,16-dihydroxyoctadec-10-ene-12,14-diy-n-1-yl acetate(4),toonapolyyne A(5),toonasindiyne B(6),scopoletin(7),sco-parone(8),3-O-acetyl(-)-epicatechin(9),p-ethoxyacetanilide(10),kulonic acid(11),β-sitosterol-3-O-β-D-glucopyranoside(12),vanillic acid(13),cleomiscosin A(14),(-)-isolariciresinol(15),resveratrol(16).The IC50 values of compounds 3-4,6,11-13 for NO were 6.90,10.49,20.03,9.49,18.34,24.36 μmol/L,respectively.CONCLUSION Compound 1 is a new polyacetylene,8-16 are isolated from T.sinensis for the first time.Compounds 3-4,6,11-13 have good anti-inflammatory activity.
