Preparation of oral lyophilized tablets of gastrodin-coated micropowder
10.3969/j.issn.1001-1528.2025.09.005
- VernacularTitle:天麻素包衣微粉口服冻干片制备
- Author:
Wei-ting WANG
1
;
Zhi-ling XIONG
;
Xin ZHAO
;
Zhi-gang LIU
Author Information
1. 天津中医药大学,天津 301617;华润三九医药股份有限公司,广东 深圳 518110
- Publication Type:Journal Article
- Keywords:
gastrodin;
coated micropowder;
oral lyophilized tablets;
preparation;
fluidized bed bottom spray method;
Box-Behnken method;
quality evaluation
- From:
Chinese Traditional Patent Medicine
2025;47(9):2856-2862
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare the oral lyophilized tablets of gastrodin-coated micropowder.METHODS Fluidized bed bottom spray method was adopted in the preparation of coated micropowder,after which the oral lyophilized tablets were further prepared.With mannitol consumption,pullulan consumption and xanthan gum consumption as influencing factors,comprehensive score for appearance traits,moisture,disintegration time and the sedimentation volume ratio as an evaluation index,the formulation was optimized by Box-Behnken method,then the taste-masking effect,appearance traits,moisture,disintegration time,content uniformity and dissolution rate were investigated.RESULTS The optimal formulation was determined to be 44.20 mg/tablet for mannitol consumption,3.70 mg/tablet for pullulan consumption,1.30 mg/tablet for xanthan gum consumption,66.67 mg/tablet for coated micropowder,and 1.5 mg/tablet for sucralose micropowder,the comprehensive score was 17.43.The obtained oral lyophilized tablets demonstrated good taste-masking effect,appearance traits and content uniformity with the disintegration time of 3-5 s,whose dissolution rates were less than 5％within 3 min in the simulated oral environment(phosphate buffer solution at pH 6.8)and more than 85％within 15 min in the simulated gastric environment(hydrochloric acid solution at pH 1.2).CONCLUSION The oral lyophilized tablets of gastrodin-coated micropowder display good taste,ease of swallowing and simple and feasible preparation process,which can provide a new idea for the taste improvement of other oral lyophilized tablets and unpleasant-smelling raw medicines.
