Analysis and evaluation of guideline-directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction
10.3969/j.issn.1673-9701.2025.28.014
- VernacularTitle:慢性射血分数降低的心力衰竭住院患者指南导向药物应用分析与评价
- Author:
Jie CAI
1
;
Chenyuan HAN
1
Author Information
1. 浙江中医药大学附属温岭中医院药剂科,浙江温岭 317500
- Publication Type:Journal Article
- Keywords:
Heart failure with reduced ejection fraction;
Guideline-directed medical therapy;
Drug evaluation
- From:
China Modern Doctor
2025;63(28):64-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the basic situation and rationality of guideline-directed medical therapy(GDMT)in hospitalized patients with chronic heart failure with reduced ejection fraction(HFrEF),and to provide a reference for clinical medication.Methods The clinical date of HFrEF patients admitted to Wenling Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University and the application of GDMT-related medications[including angiotensin receptor neprilysin inhibitor(ARNI)/angiotensin converting enzyme inhibitor(ACEI)/angiotensin Ⅱ receptor blocker(ARB),β-blocker(BB),mineralocorticoid receptor antagonist(MRA)and sodium-glucose linked transporter 2 inhibitor(SGLT2i)]were retrospectively analyzed from January 2022 to December 2024.The rationality of medicates was evaluated according to relevant guidelines/consensus and drug instructions.Results A total of 117 patients were included,among which 73.50％were male,and the average age was(69.62±14.39)years old.The proportion of patients receiving ARNI/ACEI/ARB,BB,MRA and SGLT2i was 77.78％,63.25％,97.44％and 68.38％,respectively.The rates of reaching target dose were 2.20％,0,100.00％and 98.75％,respectively.Single,double,triple and quadruple anti-heart failure drugs accounted for 5.98％,23.08％,29.06％and 41.88％,respectively.Conclusion There is still a certain gap between clinical practice and guideline in the utilization of the GDMT-realted medications in patients with chronic HFrEF in this hospital.The usage rate of BB is low,and the dosage of ARNI/ACEI/ARB and BB are seriously insufficient,while MRA is overused.The standardization of GDMT medication needs further improvement.
