Application of molecular diagnostic technology in detecting variants of pathogens causing major infectious diseases
10.3760/cma.j.cn114452-20241030-00595
- VernacularTitle:分子诊断技术在重大传染病病原体变异检测中的应用
- Author:
Bin ZHAO
1
;
Danni WANG
1
;
Xiaoxu HAN
1
Author Information
1. 传染病重症诊治全国重点实验室，国家卫生健康委员会艾滋病防治重点实验室，国家医学检验临床医学研究中心，中国医科大学附属第一医院，沈阳110001
- Publication Type:Journal Article
- Keywords:
Molecular diagnostic techniques;
Coronavirus;
Mycobacterium tuberculosis;
Human immunodeficiency virus;
Mutation
- From:
Chinese Journal of Laboratory Medicine
2025;48(4):433-440
- CountryChina
- Language:Chinese
-
Abstract:
The variants of pathogens causing major infectious diseases have a significant impact on the prevention, diagnosis, and treatment of these diseases. Rapid identification and efficient treatment rely on the detection and identification technologies for these variants. Molecular diagnostic techniques have greatly improved the sensitivity, specificity, and speed of detecting variants of major infectious diseases. With the rapid advancement of sequencing technologies, both second-generation and third-generation sequencing have shown substantial potentials in identifying variants of major infectious diseases. This article reviews the research and application status of molecular diagnostic techniques for variants of severe acute respiratory coronavirus-2, mycobacterium tuberculosis, and human immunodeficiency virus, and prospects development directions in this field, aiming to provide references for the detection and identification of major infectious diseases variants.
