Construction of a predictive model for clinical pregnancy of IVF-ET in patients with secondary infertility
10.3969/j.issn.1673-9701.2025.28.010
- VernacularTitle:继发性不孕患者IVF-ET临床妊娠的预测模型构建
- Author:
Qiankun WEI
1
;
Yun WU
;
Xinyan XU
;
Mengke WEI
;
Zhiping ZENG
;
Yuning DAI
;
Ainiwaer PATIMAN
;
Jing ZHANG
Author Information
1. 石河子大学医学院,新疆石河子 832000
- Publication Type:Journal Article
- Keywords:
Secondary infertility;
In vitro fertilization-embryo transfer;
Clinical pregnancy;
Nomogram;
Prediction
- From:
China Modern Doctor
2025;63(28):43-47,77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors of the success of clinical pregnancy in secondary infertility patients undergoing in vitro fertilization-embryo transfer(IVF-ET)and construct a nomogram prediction model.Methods A retrospective analysis was conducted on the clinical data of 235 patients with secondary infertility who underwent IVF-ET at Urumqi Maternal and Child Health Hospital from January 2020 to December 2023.They were divided into successful pregnancy group(n=109)and failed pregnancy group(n=1 26)based on whether clinical pregnancy was successful.The general information,ovulation induction data and embryo data of two groups of patients were compared.Multivariate Logistic regression analysis was used to screen out statistically significant indicators,and based on this,a nomogram prediction model was constructed.The receiver operating characteristic curve,calibration curve and decision analysis curve were drawn to verify the discrimination,accuracy and clinical practicability of the model.Results The results of multivariate Logistic regression analysis showed that the female's age,overweight and obesity were all risk factors for clinical pregnancy failure,while anti-Müllerian hormone(AMH)and the total amount of gonadotropins(Gn)were protective factor for clinical pregnancy outcomes.On this basis,a nomogram prediction model was successfully constructed,which has a medium degree of discrimination,good accuracy and clinical practicability.Conclusion For secondary infertility patients undergoing IVF-ET,the female's age,overweight and obesity,AMH,and the total amount of Gn have certain influences on clinical pregnancy.The clinical pregnancy outcome can be predicted through the constructed nomogram prediction model.
