The current status and progress in the isolation of circulating fetal cells
10.3760/cma.j.cn114452-20240419-00199
- VernacularTitle:循环胎儿细胞的分离、富集现状与进展
- Author:
Yida SU
1
;
Xiaoting LING
;
Zuhao WU
;
Yifang HUANG
Author Information
1. 广西医科大学第一附属医院检验科，广西高校临床检验诊断学重点实验室，南宁 530021
- Publication Type:Journal Article
- Keywords:
Prenatal diagnosis;
Circulating fetal cells;
Isolation methods;
Microfluidics;
Nanomaterials and microsphere materials
- From:
Chinese Journal of Laboratory Medicine
2025;48(3):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Circulating fetal cells have been proven to contain complete cellular structures and comprehensive fetal genome information, enabling non-invasive prenatal diagnosis of aneuploidy diseases, chromosomal microdeletions, and monogenic diseases. However, due to the low abundance of these rare fetal cells in maternal peripheral blood, their isolation and detection remains challenging. In recent years, novel isolation and enrichment techniques, such as microfluidic technologies and novel nanomaterials, for circulating fetal cells enrichment have been continuously advancing.This review provides a comprehensive summary of two novel methodologies for the isolation and enrichment of circulating fetal cells. Their separation principles, advantages, limitations, as well as the separation efficiencies will also be described.
