TyG index and 2-year cognitive function changes in the elderly:A longitudinal study
10.3969/j.issn.1673-9701.2025.28.009
- VernacularTitle:老年TyG指数与2年认知功能变化的纵向分析
- Author:
Jingfen XU
1
;
Lili LIN
1
;
Rongzhou YE
1
;
Xiuyan LI
1
;
Qian LI
1
Author Information
1. 福建医科大学附属泉州第一医院全科医学科,福建泉州 362000
- Publication Type:Journal Article
- Keywords:
Elderly;
Triglyceride glucose index;
Montreal cognitive assessment;
Cognitive function decline
- From:
China Modern Doctor
2025;63(28):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the triglyceride glucose(TyG)index and 2-year cognitive function changes.Methods A total of 101 elderly patients who were hospitalized at Quanzhou First Hospital Affiliated to Fujian Medical University from September to December 2022 were selected.The cognitive function was evaluated using Montreal cognitive assessment(MoCA)scale.According to the baseline TyG index,the subjects were divided into high TyG index group(TyG index≥ 8.79,51 cases)and low TyG index group(TyG index＜8.79,50 cases).Using a binary Logistic regression model to adjust for confounding factors,the association between TyG index and cognitive decline was analyzed.Results The Spearman correlation analysis results showed that TyG index was negatively correlated with the change value of cognitive function(r=-0.243,P＜0.05).The incidence of cognitive function decline in high TyG index group was significantly higher than that in low TyG index group(43.1％vs.24.0％,P=0.042).After adjusting for confounding factors,the risk of cognitive function decline in high TyG index group was 2.971 times that of low TyG index group(P＜0.05).Conclusion The TyG index of elderly hospitalized patients is correlated with 2-year cognitive function changes.The TyG index may serve as a potential biomarker for early detection of cognitive function decline.
