Update of molecular diagnostic methods in invasive Aspergillosis
10.3760/cma.j.cn114452-20241218-00691
- VernacularTitle:分子检测技术在临床侵袭性曲霉病诊断中的应用进展
- Author:
Shuangshuang YANG
1
;
Shifeng HUANG
1
;
Chuanming ZHANG
1
;
Linbo ZHANG
1
;
Ju CAO
1
Author Information
1. 重庆医科大学附属第一医院，重庆市真菌病监测网，重庆 400016
- Publication Type:Journal Article
- Keywords:
Aspergillosis;
Polymerase chain reaction;
Metagenomic next-generation sequencing;
Nanopore sequencing;
Cell free DNA
- From:
Chinese Journal of Laboratory Medicine
2025;48(2):297-302
- CountryChina
- Language:Chinese
-
Abstract:
Invasive Aspergillosis (IA) is a severe filamentous fungal infection caused by opportunistic pathogenic Aspergillus. Due to its insidious incidence and high mortality rate, accurate diagnosis of IA is in urgent need. Recent advances in molecular diagnostic techniques have enabled novel approaches for Aspergillus detection in clinical fungal laboratory. To this end, this paper summarizes recent progress in molecular detection of Aspergillus nucleic acids and discusses its value in IA diagnosis. The findings provide guidance for both current diagnostic approaches and the development of new in vitro diagnostic technologies for IA.
