Research progress on the role and mechanism of liver macrophages in chronic hepatitis B virus infection
10.3760/cma.j.cn114452-20240814-00453
- VernacularTitle:肝脏巨噬细胞在慢性乙型肝炎病毒感染中的研究进展
- Author:
Hongyan GUO
1
;
Ya FU
1
;
Qishui OU
1
Author Information
1. 福建医科大学附属第一医院检验科 福建省检验医学重点实验室 福建医科大学附属第一医院滨海院区国家区域医疗中心 福建医科大学基因诊断研究中心，福州 350005
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatic macrophage;
Immune microenvironment;
Immunological serum biomarkers
- From:
Chinese Journal of Laboratory Medicine
2025;48(1):153-158
- CountryChina
- Language:Chinese
-
Abstract:
Liver macrophages are crucial components of innate immune system in liver and play a pivotal role in chronic hepatitis B virus (HBV) infection. Influenced by the liver microenvironment, liver macrophages can exhibit diverse immunophenotypes and functions, which contribute to either inhibiting HBV infection or mediating immune tolerance. Additionally, HBV actively regulates the phenotype of liver macrophages, thereby facilitating continuous viral infection. Given that the interaction between liver macrophages and HBV might directly impact the outcome of HBV infection, the huge potential clinical value of targeting macrophage markers, this review highlights the research progress on liver macrophages in HBV infection from three aspects: the origin and heterogeneity of liver macrophages, the interaction between liver macrophages and HBV, and the potential serological immune markers associated with macrophages in HBV infection.
