Clinical characteristics analysis of patients with invasive Klebsiella pneumoniae liver abscess syndrome
10.3760/cma.j.cn114452-20240712-00368
- VernacularTitle:侵袭性肺炎克雷伯菌肝脓肿综合征的临床特征分析
- Author:
Xinrui YANG
1
;
Binghuai LU
1
Author Information
1. 中国医学科学院 北京协和医学院中日友好医院呼吸与危重症医学科临床微生物与感染实验室，北京 100029
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Liver abscess;
Clinical characteristics
- From:
Chinese Journal of Laboratory Medicine
2025;48(1):110-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and prognosis of Klebsiella pneumoniae liver abscess with extrahepatic invasive infection.Methods:We collected and analyzed clinical data from patients diagnosed with invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) at China-Japan Friendship Hospital from March 2017 to March 2023. The analysis summarized the clinical characteristics and prognosis of these patients based on the clinical information, laboratory tests, and imaging findings.Results:The clinical characteristics included chills, fever, abdominal pain, nausea, and vomiting. Eight cases showed elevated total white blood cell counts, while 9 cases had increased neutrophil counts. Abdominal imaging typically showed low-density massesor patchy shadows in the liver. Nine cases were complicated by lung abscesses, 1 case by bilateral pyopneumothorax, 1 case by abdominal and splenic abscesses, 2 cases by endophthalmitis. Seven patients were initially treated with carbapenem antibiotics alone, and 4 received combination therapy. Nine patients improved and were discharged, while 1 patient′s condition worsened and died.Conclusions:The clinical manifestations of Klebsiella pneumoniae liver abscess with extrahepatic invasive infection are nonspecific, and the onset is insidious with rapid disease progression. Early imaging and microbiological examinations should be performed to confirm the diagnosis and screen all infection sites. Timely antimicrobial therapy and drainage are essential for improving the prognosis.
