Research update on the clinical application of multi-dimension laboratory markers in primary liver cancer
10.3760/cma.j.cn114452-20240724-00402
- VernacularTitle:多维度原发性肝癌实验诊断指标的临床应用
- Author:
Chenjun HUANG
1
;
Chunfang GAO
1
Author Information
1. 上海中医药大学附属岳阳中西医结合医院临床检验实验医学中心，上海 200437
- Publication Type:Journal Article
- Keywords:
Primary liver cancer;
MicroRNA;
Glycomics;
Hepatitis B virus;
Genomics
- From:
Chinese Journal of Laboratory Medicine
2025;48(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Single biomarker could not meet the clinical diagnostic and therapeutic needs in primary liver cancer (PLC) now. Based on the relevant researches and consensus from clinical guidelines, present review addresses the progress, application, and future prospects of multidimensional biomarkers, including models such as GALAD, GALAD-like algorithms (C-GALAD, C-GALADII, GALAD-C), microRNAs, glycoprotein glycome, and the hepatitis B virus genome in the clinical diagnostic and therapeutic applications. This review aims to illustrate the important practical significance of multidimensional application of biomarkers for high-risk prediction, disease diagnosis, therapeutic monitoring, and prognosis evaluation in the clinical management of PLC.
