New perspective of diagnosis and treatment of hepatocellular carcinoma complicated with portal vein tumor thrombosis
10.3760/cma.j.cn112139-20240910-00419
- VernacularTitle:肝癌合并门静脉癌栓的诊疗新视角
- Author:
Shuyou PENG
1
;
Yihang WANG
1
;
Yun JIN
1
;
Jiangtao LI
1
Author Information
1. 浙江大学医学院附属第二医院肝胆胰外科，杭州310009
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Neoplasm metastasis;
Portal vein tumor thrombosis;
New classification;
Thrombectomy first
- From:
Chinese Journal of Surgery
2025;63(2):102-106
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) stands as the predominant type of primary liver cancer, frequently accompanied by portal vein tumor thrombosis (PVTT). PVTT is a harbinger of a grim prognosis, with current treatment modalities falling short of expectations. Delving deeper into the pathophysiology of PVTT, researchers have come to recognize that PVTT and HCC may originate from different clones. Previous clinical investigations have proposed various PVTT classification systems, offering a scientific basis for individualized and precise treatment. The innovative surgical approach of “thrombectomy first” is designed to mitigate the risk of tumor spread, thereby enhancing patient outcomes. Moreover, the multidisciplinary and integrated treatment model, including targeted therapy, immunotherapy and radiotherapy, has demonstrated promising efficacy for the treatment of PVTT. With the continuous progress and optimization of PVTT diagnostic technology, classification systems and precision treatment strategies, the prospects for long-term survival in HCC patients with PVTT are poised to see a significant uplift.
