The application progress of multiparameter flow cytometry in the field of immune senescence
10.3760/cma.j.cn114452-20240626-00329
- VernacularTitle:多参数流式细胞术在免疫衰老领域的应用进展
- Author:
Nannan LI
1
;
Bo PANG
1
Author Information
1. 中国中医科学院广安门医院检验科，北京 100053
- Publication Type:Journal Article
- Keywords:
Flow cytometry;
Immunesenescence;
Aging
- From:
Chinese Journal of Laboratory Medicine
2024;47(12):1481-1486
- CountryChina
- Language:Chinese
-
Abstract:
Immunesenescence is an important component of human aging and is closely associated with age-related diseases such as cancer, cardiovascular disease, and increased risk of infection. Detection of immune cell senescence markers by flow cytometry provides a means to assess the senescence status of various immune cells. Current studies on immunesenescence are mostly focused on specific immune cell subpopulations with limited reports describing the senescence markers of different types of immune cells in the panorama. Given variety of immune cells, the aging markers differed across cell types. This paper provides a comprehensive analysis of the aging-related flow cytometry biomarkers of different types of immune cells such as neutrophils, macrophages and dendritic cells, congenital lymphocytes, acquired lymphocytes and unconventional T lymphocytes. The detection of these markers by flow cytometry is advantageous in depicting the immune senescence status of the human body and may also be useful in the future for evaluating interventions and therapies against age related diseases. However, challenges such as such as inconsistent detection protocols for refined subpopulations of immune cells and conflicting research results need further investigation to promote the clinical application of flow cytometry technology in the assessment of immune senescence.
