Mechanisms, prevention and treatment strategies of cat allergen sensitization
10.3760/cma.j.cn112150-20250416-00321
- VernacularTitle:猫变应原致敏的机制及防治策略研究
- Author:
Yanbing CHEN
1
;
Lin JIANG
1
;
Min ZHANG
1
Author Information
1. 南京医科大学第一附属医院 江苏省人民医院耳鼻咽喉科&过敏诊疗中心，南京 210029
- Publication Type:Journal Article
- Keywords:
Cat allergens;
Allergic diseases;
Component resolved diagnostics;
Allergen immunotherapy;
Prevention
- From:
Chinese Journal of Preventive Medicine
2025;59(9):1372-1380
- CountryChina
- Language:Chinese
-
Abstract:
Cat allergens are among the most significant environmental factors contributing to the onset of allergic diseases. The increasing global prevalence of pet cat ownership in recent years has been associated with a rise in the incidence of allergic diseases linked to cat allergens. Research has demonstrated that pet cats can trigger type I hypersensitivity-related conditions, such as allergic rhinitis, asthma, and atopic dermatitis, in atopic individuals through allergens found in their dander, saliva, urine, and other substances. The precise mechanism by which cat allergens induce immune tolerance remains incompletely understood. Furthermore, due to the complexities of multiple sensitizations and cross-reactivity, the interactions between cat allergens and other pet allergens (e.g., dog allergens) and air pollutants in the development of allergic diseases are not yet fully elucidated. Consequently, this article reviews recent advancements in the epidemiology of cat allergen sensitization, the underlying mechanisms, exposure and sensitization risks, component-resolved diagnostics, treatment, and prevention, with the aim of providing references for clinical strategies in the prevention, diagnosis, and management of these conditions.
