Association of blood selenium exposure with sex hormones among men aged 18-79 years in China
10.3760/cma.j.cn112150-20250420-00333
- VernacularTitle:中国18~79岁成年男性血硒水平与性激素的关联性研究
- Author:
Zheng LI
1
;
Yingli QU
;
Yawei LI
;
Saisai JI
;
Haocan SONG
;
Qi SUN
;
Miao ZHANG
;
Wenli ZHANG
;
Jiayi CAI
;
Liang DING
;
Ying ZHU
;
Feng ZHAO
;
Zhaojin CAO
;
Yuebin LYU
;
Lu WANG
;
Xiaoming SHI
Author Information
1. 中国疾病预防控制中心性病艾滋病预防控制中心，北京 102206
- Publication Type:Journal Article
- Keywords:
Selenium;
Sex hormones;
Testosterone;
Cross-sectional studies
- From:
Chinese Journal of Preventive Medicine
2025;59(10):1632-1639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between blood selenium levels and sex hormones in Chinese men aged 18-79 years.Methods:Data were derived from the China National Human Biomonitoring survey conducted in 2017-2018, with a final sample size of 5 414 men. General demographic characteristics, behavioral habits, and dietary frequency were collected through questionnaires and physical examinations. Fasting blood samples were collected to measure blood lead, serum testosterone, and estradiol levels. Complex sampling linear regression models were used to analyze the associations between blood selenium levels and testosterone, estradiol, and the testosterone/estradiol ratio, adjusting for confounding factors including age, education level, marital status, smoking status, alcohol consumption, seafood intake, soy product intake, protein supplement intake, BMI, and diabetes status.Results:The mean age of the 5 414 participants was (46.85±27.91) years; 4 774 (91.65%) were of Han ethnicity and 4 505 (86.68%) were married. The median ( Q1, Q3) blood selenium concentration in men was 97.80 (80.64, 116.99) μg/L. After adjusting for confounding factors, the complex sampling linear regression model revealed negative associations between blood selenium levels and both testosterone levels and the testosterone/estradiol ratio, with a significant linear trend ( Ptrend<0.05). Compared with the Q1 group, the β (95% CI) values for testosterone in the Q2, Q3, and Q4 groups were -0.02 (-0.06 to 0.02), -0.03 (-0.08 to 0.01), and -0.06 (-0.09 to -0.02), respectively. Similarly, the β (95% CI) values for the testosterone/estradiol ratio in the Q2, Q3, and Q4 groups were -0.01 (-0.03 to 0.02), -0.01 (-0.04 to 0.04), and -0.03 (-0.06 to -0.01), respectively. Subgroup analysis indicated stronger associations between blood selenium levels and testosterone/estradiol levels in non-smoking and obese men (BMI≥28 kg/m2). Conclusion:Blood selenium levels are negatively associated with testosterone levels and the testosterone/estradiol ratio in Chinese adult males.
