Parent-of-origin effect and its research progress in cardio-metabolic diseases
10.3760/cma.j.cn112150-20240922-00763
- VernacularTitle:亲源效应及其在心血管代谢性疾病中的研究进展
- Author:
Hexiang PENG
1
;
Mengying WANG
;
Siyue WANG
;
Huangda GUO
;
Tianjiao HOU
;
Yixin LI
;
Hanyu ZHANG
;
Yiqun WU
;
Xueying QIN
;
Jin LI
;
Dafang CHEN
;
Yonghua HU
;
Tao WU
Author Information
1. 中南大学湘雅公共卫生学院流行病与卫生统计学系，长沙410013
- Publication Type:Journal Article
- Keywords:
Parent-of-origin effect;
Genomic imprinting;
DNA methylation;
Cardiometabolic diseases
- From:
Chinese Journal of Preventive Medicine
2025;59(9):1552-1558
- CountryChina
- Language:Chinese
-
Abstract:
Genomic imprinting refers to the phenomenon of differential expression of two alleles due to their different parental origins. Genes that produce genomic imprinting are usually called imprinted genes. The genetic effect caused by the presence of imprinted genes is called parent-of-origin effect. Parent-of-origin effect and genomic imprinting play important roles in the pathophysiological mechanism and occurrence and development of cardio-metabolic diseases. In-depth exploration of the law and potential roles of imprinted genes and parent-of-origin effects will help to better understand the mechanism of cardio-metabolic diseases, and also provide important theoretical basis for the precise treatment of diseases related to imprinted genes.
