Correlation between serum 25-hydroxyvitamin D levels and 24-h urinary calcium excretion and hypercalciuria in Chinese adults
10.3760/cma.j.cn112138-20240929-00619
- VernacularTitle:中国成人血清25羟维生素D水平与24小时尿钙排泄量及高钙尿症的相关性分析
- Author:
Li SHEN
1
;
Hao ZHANG
;
Qi LU
;
Shanshan LI
;
Chao GAO
;
Yazhao MEI
;
Hua YUE
;
Xiangtian YU
;
Qi YAO
;
Yanan HUO
;
Yuhong ZENG
;
Yin JIANG
;
Zhongjian XIE
;
Aijun CHAO
;
Xiaolan JIN
;
Li MAO
;
Zhenlin ZHANG
Author Information
1. 上海交通大学医学院附属第六人民医院临床研究中心 骨质疏松和骨病专科，上海 200233
- Publication Type:Journal Article
- Keywords:
25-Hydroxyvitamin D;
Hypercalciuria;
Urinary calcium excretion;
Cross-sectional studies;
Correlation analysis
- From:
Chinese Journal of Internal Medicine
2025;64(4):318-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and 24-h urinary calcium excretion (24-h UCaE) and hypercalciuria in Chinese adults.Methods:This cross-sectional study was conducted from March 2022 to March 2023 in nine cities in China and included 1 239 residents. Demographic characteristics were collected through questionnaires and physical examinations, fasting blood samples were assessed for bone metabolism indicators, and 24-h urine samples were used to determine the 24-h UCaE. Multiple linear regression analysis was used to explore the relationship between serum 25(OH)D and 24-h UCaE and bone metabolism indexes. The relationship between serum 25(OH)D and hypercalciuria was analyzed using a multiple logistic regression model combined with restricted cubic spline modeling.Results:The mean participant age was (47.9±18.1) years, of which 453 (36.6%) were male. The percentages of vitamin D sufficiency, insufficiency, and deficiency were 7.6% (94/1 239), 29.0% (359/1 239), and 63.4% (786/1 239), respectively. The multiple linear regression model showed that after adjusting for the covariates the 24-h UCaE gradually increased with higher levels of 25(OH)D ( P overall <0.001, P nonlinear <0.001). The logistic regression analysis revealed that compared with the vitamin D deficient group, the OR for the prevalence of hypercalciuria in the vitamin D sufficient and vitamin D insufficient groups were 3.290 (95% CI 1.745 to 6.202) and 3.742 (95% CI 2.458 to 5.697), respectively. The results of the restricted cubic spline modeling showed a positive nonlinear relationship between 25(OH)D and the prevalence of hypercalciuria ( P overall <0.001, P nonlinear <0.001). The prevalence of hypercalciuria increased when 25(OH)D was >17.00 μg/L and peaked at 26.71 μg/L, after which there was a decreasing trend in the prevalence of hypercalciuria with increasing 25(OH)D. Conclusion:Associations between serum 25(OH)D levels and urinary calcium excretion and the prevalence of hypercalciuria were observed in the Chinese adult population.
