Clinical characteristic analysis of refractory Helicobacter pylori infection of 637 patients
10.3760/cma.j.cn112138-20241030-00714
- VernacularTitle:难治性幽门螺杆菌感染637例患者临床特征分析
- Author:
Baojun SUO
1
;
Yuxin ZHANG
1
;
Cailing LI
1
;
Liya ZHOU
1
;
Zhiqiang SONG
1
Author Information
1. 北京大学第三医院消化科，北京 100191
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Refractory;
Treatment;
Safety
- From:
Chinese Journal of Internal Medicine
2025;64(3):220-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effectiveness of empiric eradication therapy recommendations and medication principles for refractory infections based on the 2022 Helicobacter pylori ( H. pylori) infection treatment guidelines in China in clinical practice. Methods:A retrospective analysis was conducted to evaluate the eradication efficacy of H. pylori and the safety and treatment compliance among of 637 patients with refractory H. pylori infection in our center over the past 10 years. Risk factors affecting efficacy of H. pylori eradication were evaluated. Results:The overall eradication rate, incidence of adverse reactions and medication percentage of 14-day bismuth quadruple therapy were 92.3%, 40.3% and 92.2%, respectively. The eradication rate, incidence of adverse reactions, and proportion of administered treatments were as follows: 87.3%, 36.4% and 92.7% for amoxicillin+metronidazole; 91.1%, 39.2% and 93.7% for amoxicillin+tetracycline; 92.9%, 23.8% and 94.0% for amoxicillin+furazolidone; 92.1%, 47.1% and 90.0% for tetracycline+metronidazole; 94.5%, 41.7% and 92.0% for tetracycline+furazolidone, and 91.3%, 46.3% and 92.5% for furazolidone+metronidazole. Poor compliance was a risk factor for the failure of eradication therapy (94.7% vs. 64.0%, P<0.05). There was no statistically significant difference ( P>0.05) in the eradication rate among patients in terms of sex, age, body mass index, smoking status, alcohol consumption, previous eradication frequency, eradication interval, or eradication regimens. Conclusion:The empirical treatment regimens and medication principles recommended in the 2022 H. pylori infection treatment guidelines in China achieve good eradication efficacy, safety, and compliance.
