Advances in the diagnosis and treatment of Balo′s concentric sclerosis
10.3760/cma.j.cn113694-20250403-00188
- VernacularTitle:Balo同心圆硬化的诊疗进展
- Author:
Ziyu WANG
1
;
Yulan ZHU
1
Author Information
1. 哈尔滨医科大学附属第二医院神经内科，哈尔滨 150086
- Publication Type:Journal Article
- Keywords:
Balo′s concentric sclerosis;
Encephalitis periaxialis concentrica;
Demyelinating diseases
- From:
Chinese Journal of Neurology
2025;58(11):1240-1244
- CountryChina
- Language:Chinese
-
Abstract:
Balo′s concentric sclerosis (BCS) is a rare demyelinating disease of the central nervous system, once considered a variant of multiple sclerosis. It is characterized by alternating layers of demyelinated and myelinated regions in a concentric pattern, resembling tree rings. The disease typically has an acute onset and diverse clinical manifestations. In the past, diagnosis of BCS primarily relied on autopsy; however, with the widespread application of magnetic resonance imaging, the number of confirmed cases has gradually increased, significantly improving the efficiency of clinical diagnosis and treatment. Nevertheless, most reports both domestically and internationally remain limited to individual cases. This article provides a review of the epidemiology, etiology, predisposing factors, pathogenesis, neuropathological features, clinical manifestations, differential diagnosis, relationship with multiple sclerosis, auxiliary examinations, and treatment of BCS.
