Research progress of childhood obesity based on genomic and epigenomic biomarkers
10.3760/cma.j.cn112150-20240729-00606
- VernacularTitle:基因组和表观基因组生物标志物与儿童肥胖的研究进展
- Author:
Zhiwei XIA
1
;
Hai ZHAO
;
Tingting LIU
;
Yan LI
;
Junsheng HUO
;
Xin GUO
Author Information
1. 北京市疾病预防控制中心学校卫生所，北京 100013
- Publication Type:Journal Article
- Keywords:
Children;
Obesity;
Biomarkers;
Genomics;
Epigenomics
- From:
Chinese Journal of Preventive Medicine
2025;59(7):1125-1130
- CountryChina
- Language:Chinese
-
Abstract:
Obesity represents a complex, heritable condition shaped by interactions among genetic, epigenetic, metagenomic, and environmental factors. Nevertheless, the mechanistic contributions of genetic variation and epigenetic regulation to obesity pathogenesis remain incompletely elucidated. Advances in molecular profiling technologies have enabled the identification of numerous biomarkers associated with childhood obesity phenotypes. These discoveries facilitate understanding of obesity etiology and its links to chronic diseases. This review synthesizes current research on genomic and epigenomic biomarkers influencing childhood obesity susceptibility, advances our comprehension of etiological heterogeneity and intervention strategies, and offers conceptual frameworks for precision prevention based on epigenetic mechanisms.
