The research progression of single-molecule array technology in cancer precise diagnosis and treatment
10.3760/cma.j.cn114452-20241227-00713
- VernacularTitle:单分子阵列技术在癌症精准诊疗中应用的研究进展
- Author:
Kunyi WANG
1
;
Nan LIANG
1
;
Hui SUN
1
Author Information
1. 吉林大学中日联谊医院甲状腺外科，长春 130033
- Publication Type:Journal Article
- Keywords:
Single Molecule Imaging;
Cancer;
Biomarker
- From:
Chinese Journal of Laboratory Medicine
2025;48(10):1363-1368
- CountryChina
- Language:Chinese
-
Abstract:
Various methods for cancer biomarker detection have been developed to realize cancer early diagnosis, precise treatment, and prognosis evaluation. Traditional techniques such as ELISA (enzyme-linked immunosorbent assay)have been widely applied worldwide, but face challenges in standardized wide application due to molecular-level limitations, sensitivity, and application scope. In 2014, the ultra-sensitive Simoa (Single Molecule Array) technology was introduced, breaking through the shortcomings of small-molecule detection. Simoa enables highly efficient detection and quantitative analysis of biomarkers across multiple fields, providing new insights into cancer biomarker tests. Simoa demonstrates significant advantages in biomarker detection and clinical application, with a wide clinical application prospect in the diagnosis and treatment of lung cancer, breast cancer and other cancers, and provides a theoretical basis for the construction of cancer prediction model.
