Research progress on small extracellular vesicles in the diagnosis and treatment of colorectal cancer
10.3760/cma.j.cn114452-20241227-00712
- VernacularTitle:小细胞外囊泡在结直肠癌诊疗中的研究进展
- Author:
Xiangxiao LI
1
;
Shiwen WANG
1
Author Information
1. 复旦大学附属华东医院检验科，上海 200040
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Small extracellular vesicles;
MiRNA;
LncRNA;
CircRNA
- From:
Chinese Journal of Laboratory Medicine
2025;48(10):1358-1362
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a malignant tumor of the digestive system that seriously endangers human health. Small extracellular vesicles (sEV) are a class of extracellular vesicles with lipid bilayer structure with diameter less than 200 nm. SsEV mediate cell-to-cell information exchange through a variety of components. MicroRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA) and proteins are involved in regulating the occurrence and development of colorectal cancer and play important roles in the diagnosis and prognosis of colorectal cancer. The various active components of sEV hold application value in the 'diagnosis-treatment-prognosis' of colorectal cancer, providing a reference for their application prospects.
