A case of clinical features of discordant lymphoma with MYD88 genetic aberration
- VernacularTitle:MYD88遗传学异常的不一致性淋巴瘤1例
- Author:
Hong ZHOU
1
;
Weiwei ZHAO
1
;
Juan LIU
1
;
Yanming XUE
1
;
Liyan CHEN
1
;
Wenbo YANG
1
;
Wei WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Lymphoma; Bone marrow involvement; Inconsistency
- From: Chinese Journal of Laboratory Medicine 2025;48(10):1354-1357
- CountryChina
- Language:Chinese
- Abstract: A case of 75-year-old male patient was admitted to the Second Affiliated Hospital of Harbin Medical University on June ,2024 complaining 'repeated cough for half a year', accompanied by night fever, night sweats, fatigue, weight loss. He was initially diagnosed as diffuse large B-cell lymphoma through chest CT and bronchoscopic biopsy, then confirmed as diffuse large B-cell lymphoma with MYD88 genetic aberration with bone marrow inconsistent involvement by PET-CT, bone marrow biopsy, immunohistochemistry(IHC),FISH and other tests. The R-CHOP was given as first-line regimen treatment immediately, but the patient appeared allergyic to Rituximab and Zuberitamab sequencially, therefore we change the plan to CDOP for continued chemotherapy and discharged after remission. In his regular admission, we give G-CHOP regimen for chemotherapy, no adverse reactions were found.
