A case of angioimmunoblastic T-Cell lymphoma with clonal plasma cell proliferation predominantly in the bone marrow
10.3760/cma.j.cn114452-20250327-00196
- VernacularTitle:骨髓表现以克隆性浆细胞增多为主的血管免疫母细胞性T细胞淋巴瘤1例
- Author:
Mei LIU
1
;
Na ZHANG
;
Zhanxi GAO
;
Yan ZHOU
;
Min SHI
Author Information
1. 河北医科大学第二医院检验科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Angioimmunoblastic T cell lymphoma;
cell morphology;
serum immunoglobulin
- From:
Chinese Journal of Laboratory Medicine
2025;48(10):1349-1353
- CountryChina
- Language:Chinese
-
Abstract:
A 71-year-old male patient was admitted to the Hematology Department of the Second Hospital of Hebei Medical University due to abdominal pain accompanied of chest tightness and shortness of breath, which appeared without obvious cause over a month ago, and multiple abnormal enlarged lymph nodes around the stomach.After admission, physical examination revealed an anemic appearance, serum immunofixation electrophoresis showed positivity for immunoglobulin A (IgA) and κ light chain. The cytological morphology of bone marrow, bone marrow biopsy and lymph node flow cytometry all indicated a significant proliferation of plasma cells.The preliminary clinical diagnosis is multiple myeloma.The review of bone marrow cytology revealed a small number of abnormal cells, which provided direction for the next clinical diagnosis and treatment of lymph node pathological biopsy, immunohistochemical staining, and genetic testing were performed.The patient was ultimately diagnosed with angioimmunoblastic T-cell lymphoma (AITL) with monoclonal gammopathy.After the clinical administration of the chemotherapy regimen consisting of Chidamide and CHOPE.The patient′s symptoms have improved compared with before.The treatment was effective.The AITL is a subtype of nodal T-follicular helper cell lymphoma. Which is a rare type of non-Hodgkin′s lymphoma.The cytological morphology of bone marrow, lymph node pathological biopsy and immunohistochemistry provided important basis and ideas for the correct diagnosis and treatment of the patient.
