Application of mass cytometry for clinical diagnosis, treatment and research in pediatric diseases
10.3760/cma.j.cn114452-20240510-00235
- VernacularTitle:质谱流式细胞术在儿科疾病临床诊疗与研究中的应用
- Author:
Hongqiang SHEN
1
;
Yangfan TIAN
;
Qiang SHU
Author Information
1. 浙江大学滨江研究院，杭州310053
- Publication Type:Journal Article
- Keywords:
Flow cytometry;
Mass spectrometry;
Mass cytometry by time of flight;
Pediatrics;
Immune system;
Tumor
- From:
Chinese Journal of Laboratory Medicine
2024;47(12):1386-1390
- CountryChina
- Language:Chinese
-
Abstract:
Mass cytometry by time of flight (CyTOF) combines traditional flow cytometry with mass spectrometry, allowing for high-throughput, multiplexed measurements of up to 40 parameters. It offers advantages such as unique metal label tags, no need for compensation calculations, high throughput, and diversified data processing. CyTOF has been applied in many fields of medicine, including signaling pathways, growth and development, tumor microenvironments, autoimmune diseases, infections, immunotherapy, and organ transplantation. This article reviews recent progress in the application of CyTOF in the clinical diagnosis, treatment, and research of pediatric diseases to enhance its utility in diagnosis and treatment.
