Research progress of serine protease inhibitors family in diseases
10.3760/cma.j.cn112150-20241114-00907
- VernacularTitle:丝氨酸蛋白酶抑制剂家族在疾病中的研究进展
- Author:
Yuan JIANG
1
;
Min JIANG
1
;
Yan LONG
1
Author Information
1. 广州医科大学附属妇女儿童医疗中心检验科，广州 510623
- Publication Type:Journal Article
- Keywords:
Serine protease inhibitors family;
Protease inhibitors;
Coagulation;
Inflammation;
Immune modulation
- From:
Chinese Journal of Preventive Medicine
2025;59(5):734-746
- CountryChina
- Language:Chinese
-
Abstract:
This article discusses the structure, function, signaling pathways, and disease associations of the serine protease inhibitors(SERPINS)family. The SERPINS family antagonizes the activity of serine proteases and plays critical roles in various biological processes, including coagulation, fibrinolysis, inflammatory responses, and immune modulation. SERPINS possess a conserved secondary structure and function through an irreversible suicide inhibition mechanism. Their dysfunction is associated with a multitude of clinical diseases, such as deep vein thrombosis, emphysema, dementia, and neurodegenerative disorders. Reviewing several key members of the SERPINS family, such as SERPINA1,SERPINA5,SERPINB2,SERPINC1 and SERPINE1, their physiological roles and functions, and their roles in related diseases, is of significant importance for further research into these conditions.
